Across
- 6. An enzyme necessary for the biosynthesis of ergosterol (and the therapeutic target of the azole antifungals) is _______________ 14α-demethylase
- 8. Aromatic ring in posaconazole that interacts directly with the heme iron atom in P450 enzymes
- 9. A polyene antifungal agent that, due to its extremely high toxicity, is only used topically
- 10. Because polyene antifungals contain both acidic and basic functional groups, they are classified as _______________
- 12. A solubilizing compound used in the IV formulations of voriconazole and posaconazole
Down
- 1. Newer oxaborole-containing antifungal agent for the topical treatment of onychomycosis of the toenail
- 2. Newer triterpenoid antifungal agent for the oral treatment of drug-resistant vulvovaginal candidiasis (VVC)
- 3. Lipocyclohexapeptides that inhibit the cross-linking of fungal cell wall components in a manner analogous to the penicillins and the bacterial cell wall
- 4. A component of fungal cell membranes that is structurally and functionally very similar to cholesterol
- 5. Bicyclic ring system found in all squalene epoxidase inhibitors (and the origin of the "naf" stem in the drugs' generic names)
- 7. Older fungal microtubule inhibitor used as an oral treatment for various Tinea infections
- 11. Ester _______________ is the chemical process by which the prodrug triacetin is converted to its active acetic acid (acetate) components