The Hemato-Logic Challenge

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Across
  1. 1. An inclusion body where all inclusions are spread out within the RBC.
  2. 5. A characteristic feature present in proliferating hematopoietic cells in Chronic Myelogenous Leukemia.
  3. 9. A protein that is increased in Multiple Myeloma.
  4. 10. A condition also referred to as "spoon-shaped nails".
  5. 13. Stain that gives a positive reaction to polysaccharides and is useful in the diagnosis of Erythroleukemia and ALL.
  6. 15. One of the components that basophils consist of.
  7. 16. Oxidized by MPO to a reddish-brown derivative in the presence of hydrogen peroxidase.
  8. 19. Anemia due to marrow infiltration.
  9. 22. Also known as Indolent Lymphoma, characterized by the proliferation of cells which produce a monoclonal IgM paraprotein.
  10. 24. An increase in this type of white blood cell is associated with a parasitic infection or an allergic reaction.
  11. 25. Cytochemical stain used to differentiate Acute Myeloid Leukemia (AML) from Acute Lymphoid Leukemia (ALL).
  12. 29. A decrease in the oxygen carrying capacity of the blood.
  13. 31. Severe microangiopathic anemia caused by E. coli serotype O:157 H7 that primarily affects children.
  14. 32. A lymphocyte seen in non-malignant disorders, also called an Atypical Lymphocyte, Downey Type Cell, or Turk Irritation Cell.
  15. 33. An absolute leukocyte count less than 3.0 x 10⁹/L.
  16. 35. A disorder where T cells react against B lymphocytes infected with the Epstein-Barr virus.
  17. 37. A Myeloproliferative Disorder (MPD) arising as a clonal process from a pluripotential stem cell.
  18. 38. Red blood cell fragments that appear in all Microangiopathic Hemolytic Anemia (MAHA) disorders.
  19. 39. Measures the capacity of iron to bind with transferrin.
  20. 42. A local tumorous proliferation of plasma cells in the marrow.
  21. 43. A decrease in oxyhemoglobin.
  22. 44. The condition that can result from increased bilirubin, which can damage the brain.
  23. 45. An abbreviation for Pulmonary Infiltrates with Eosinophilia.
  24. 46. Cells that give a positive reaction with the Prussian Blue / Perl's stain for iron.
  25. 47. Cytochemical stain used to differentiate Chronic Myelogenous Leukemia (CML) from a leukemoid reaction.
  26. 48. An indicator of the start of hemolysis.
  27. 50. A rough T-cell with a grooved or convoluted nucleus, seen in Sezary syndrome and mycosis fungoides.
  28. 51. The disease for which Tartrate-Resistant Acid Phosphatase (TRAP) is a diagnostic tool for confirmation.
  29. 55. Small blue-gray bodies in the cytoplasm of neutrophils that are remnants of free ribosomes, often seen in bacterial infections and severe burns.
  30. 58. The most common type of leukopenia, with an absolute neutrophil count less than 1.75-1.8 x 10⁹/L.
  31. 60. Type of esterase stain that detects the enzyme present in the primary granules of granulocytic cells.
  32. 63. A bacterial infection that is a cause of neutropenia.
  33. 65. Dark blue to purple cytoplasmic granules in neutrophils and their precursors, characteristic of bacterial infections.
  34. 67. The location where Myeloperoxidase (MPO) is present in most granulocytic cells.
  35. 72. A neoplastic clonal MPD that commonly manifests with panmyelosis and increases in RBC, granulocytes, and platelets.
  36. 73. The substance stained by Sudan Black B (SBB), appearing dense black.
  37. 74. A hypersegmented neutrophil, larger than normal, with 5-10 lobes, seen in pernicious anemia.
  38. 75. A PMN that has engulfed the nuclear material of another white cell or a lymphocyte, where the ingested nucleus is replaced by a purplish homogenous round mass.
  39. 76. Stain for iron, which gives a positive reaction in cases of ringed sideroblasts and siderocytes.
  40. 77. Cells that give a positive reaction with the Prussian Blue / Perl's stain for iron.
Down
  1. 2. A serious complication during pregnancy involving Hemolysis, Elevated Liver Enzymes, and Low Platelets.
  2. 3. Anemia common in athletes and soldiers, also known as Sports Anemia.
  3. 4. The most common metabolic disorder of RBCs involving the Hexose Monophosphate Shunt Pathway.
  4. 6. A cell where the nucleus becomes smaller and denser, and nuclear segments disappear.
  5. 7. Linear or spindle-shaped red-purple inclusions found in myeloblasts and monoblasts, derived from azurophilic granules.
  6. 8. Isoimmune HDN due to Rh incompatibility.
  7. 11. Antibodies against this related antigen give positive results in megakaryoblastic leukemia.
  8. 12. Caused by deposition of microthrombi containing RBCs, WBCs, platelets and von Willebrand factors.
  9. 14. The term for extreme neutropenia, which is an absolute neutrophil count less than 0.5 x 10⁹/L.
  10. 17. FAB classification M6, also known as DiGuglielmo syndrome.
  11. 18. A generalized neoplastic proliferation or accumulation of leukopoietic cells with or without involvement of the peripheral blood.
  12. 20. an absolute leukocyte count greater than 11.0 x 10⁹/L.
  13. 21. An absolute monocyte count greater than 0.9 x 10⁹/L.
  14. 23. A group of clonal disorders characterized by a decrease in one or more types of peripheral blood cells due to abnormal maturation.
  15. 26. One of the components that basophils consist of, along with Histamine and Heparin.
  16. 27. A rare chronic acquired defect of the RBC membrane considered to be sleep-related hemoglobinuria.
  17. 28. Classified as an MPD in which the proliferation of abnormal BM stem cells results in the replacement of marrow with fibrous connective tissue.
  18. 30. DEFICIENCY ANEMIA The most common and most treatable type of anemia.
  19. 31. A product of hemoglobin denaturation, seen in G6PD deficiency and caused by drugs or chemical agents.
  20. 34. A craving for non-edible food, such as dirt.
  21. 36. Characterized by a rapid increase in the numbers of immature blood cells.
  22. 39. A rare and potentially fatal MAHA disorder characterized by disseminated thrombotic occlusions of the microcirculation.
  23. 40. Characterized by the excessive buildup of relatively mature, but still abnormal white blood cells.
  24. 41. A net-like nucleus from a ruptured white cell, which is seen in chronic lymphocytic leukemia.
  25. 49. A condition associated with autoimmune neutropenia.
  26. 52. The hallmark cell of Hodgkin's disease, described as resembling an "owl's eye".
  27. 53. A type of lymphoma that is characterized by a negative reaction to the PAS stain.
  28. 54. Used for iron storage.
  29. 56. Also known as Albert-Bazin Syndrome, it is the most common form of cutaneous T-cell lymphoma.
  30. 57. Reactive but excessive leukocytosis characterized by the presence of immature cells in the peripheral blood, often caused by bacterial infections.
  31. 59. An absolute leukocyte count greater than 7.0-8.0 x 10⁹/L.
  32. 61. Combines with oxidized hydroxyl groups in the PAS reaction to give a bright red color product.
  33. 62. Cytochemical stain that appears dense black because it stains lipids, such as sterols, neutral fats, phospholipids, and lipoproteins.
  34. 63. Stain that differentiates basophilic leukemia and mast cell leukemia from other diseases.
  35. 64. The onset characteristic of Chronic Leukemia.
  36. 66. The most common type of Autoimmune Hemolytic Anemia, mediated by an IgG antibody with maximum binding affinity at 37°C.
  37. 68. A B-cell lymphocyte with hair-like cytoplasmic projections seen in hairy cell leukemia.
  38. 69. Measures the circulating iron bound to transferrin.
  39. 70. A type of myeloblastic leukemia that forms a green-colored tumor located outside the bone marrow.
  40. 71. A monocyte with an engulfed nucleus, usually of a lymphocyte.