Acute Leukemias: General and Stains

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Across
  1. 4. this cytochemical stain targets an enzyme located in myeloid cells, and thus can distinguish myeloid blasts from lymphoid blasts
  2. 5. leukemias originate in the __________
  3. 7. specific esterase stains can be used to identify __________ line cells
  4. 8. the current WHO system of classifying acute leukemias relies on cytogenetics, FISH, immunohistochemical stains, and __________
  5. 11. a Sudan Black B stain targets lysosomal lipids and __________ membranes
  6. 15. acute leukemia symptoms occur due to the failure of normal __________
  7. 16. for a patient's leukemia to be considered acute, a diff must show >__________% blasts
  8. 17. this lab finding can be an indicator of an acute leukemia
  9. 18. the Nonspecific Esterase stain (NSE) targets an enzyme primarily found in __________ cells
Down
  1. 1. the old French-American-British (FAB) system of classifying acute leukemias relied on cytochemical stains and cell __________
  2. 2. lymphomas originate in __________
  3. 3. congenital disorders, abnormal chromosome numbers, and chronic marrow dysfunctions are all examples of __________ risk factors for acute leukemia development
  4. 6. the periodic acid __________ stain can help identify immature granulocytes and usually is interpreted by a pathologist
  5. 7. if a patient's blood does not diff above the cutoff for acute leukemia, they could have a __________ syndrome
  6. 9. radiation, chemical exposure, drug use, and viral infections are all __________ risk factors for acute leukemia development
  7. 10. acute leukemias are seen in __________ ages
  8. 12. death from acute leukemias can occur in __________
  9. 13. cells positive with this stain are the myeloid line and monocytic line, while cells negative for this stain include lymphocytes and NRBCs
  10. 14. this type of leukemia involves a rapid, abnormal expansion of immature cells or blasts