Advanced Biochemistry Presentation

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Across
  1. 4. The central nonribosomal peptide in this paper.
  2. 5. Module 1 is considered the ___ module.
  3. 9. This group acted as a click chemistry handle for cross-coupling to a fluorescent molecule.
  4. 11. The byproduct produced from premature termination of the growing peptide chain.
  5. 14. Used this tool to determine if tyrocidine analogues were successfully synthesized and what the byproducts were.
  6. 15. Instead of being linear, tyrocidine A is a ___ peptide.
  7. 16. What type of biological activity does Tyrocidine A have?
Down
  1. 1. When reprogramming the A domain, they mutated a Tryptophan residue to ____.
  2. 2. They used a ___ exchange assay to study the kinetics of the A domain
  3. 3. Cu(I) catalyzes the cycloaddition of an alkyne and an ____.
  4. 6. ___ chemistry includes a class of high-yielding reactions that proceed selectively in biological systems without side-reactions
  5. 7. An enzyme that links building blocks together using energy from ATP.
  6. 8. Module 4 is considered an ____ module.
  7. 10. The A-domain activates amino acids through ____.
  8. 12. ___ chemistry includes a set of reactions that are fast, regiospecific, high yielding, and easy to purify
  9. 13. This amino acid is sometimes accidentally incorporated instead of the desired Phe analog.