Anaesthetics

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Across
  1. 3. most commonly used IV general anaesthetic; GABAa allosteric modulator; suitable for maintenance
  2. 4. a measure of potency for general anaesthesia; the anaesthetic concentration required to abolish response to a surgical incision in 50% of patients
  3. 7. used to speed up anaesthesia via other anaesthetic agents
  4. 8. dissociative anaesthetic; may not induce FULL unconsciousness but has a state of full analgesia, amnesia and little awareness; NMDA antagonist; suitable for maintenance; IV general anaesthetic
  5. 10. VGNaC blocker; preferred for spinal analgesia; as an epidural
  6. 11. what form of a drug is impermeable to the cell membrane
  7. 12. widely used GABAa positive modulator; inhalation anaesthetic
  8. 13. IV general anaesthetic; not for maintenance; non- analgesic effect
  9. 14. low lipophilicity; GABAa positive modulator; inhalation anaesthetic
Down
  1. 1. after entering the cell, what must a drug bind to, to attach to the voltage gated Na+ channel
  2. 2. VGNaC blocker; highly lipophilic & rapidly metabolised by plasma esterases, this minimises the systemic spread and makes it good for topical application
  3. 5. VGNaC blocker; the most common drug used for general purpose
  4. 6. partially metabolised GABAa positive modulator; risk of renal toxicity
  5. 9. ultra short acting barbiturate; not suitable for maintenance; IV general anaesthetic