Anti-platelet Agents

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Across
  1. 6. non-thienopyridines bind reversibly or irreversibly?
  2. 7. coadministration of aspirin with aminoglycosides, cisplatin, erythromycin, vancomycin and loop diuretics may potentiate ____effects
  3. 10. Ticlopidine, clopidogrel, prasugrel, ticagrelor and cangrelor are examples of what type of anti-platelet drug?
  4. 12. these drugs: ticlopidine (Ticlid), clopidogrel (Plavix) and prasugrel (Effient) are examples of a thienopyridine or non-thienopyridine?
  5. 13. what drug causes these adverse effects: acute renal insufficiency, thrombocytopenia, hepatitis, angioedema and Reye's syndrome
  6. 14. aspirin ______ (agonizes or antagonizes) uricosuric effects of phenylbutazone, probenecid and sulfinpyrazone
  7. 17. Thienopyridines bind reversibly or irreversibly?
  8. 18. dipyridamole is used in combo with aspirin to prevent?
  9. 21. drug that inhibits prostacyclin (PGI2) that inhibits platelet aggregation and reduces TXA2 production
  10. 24. first reversible oral P2Y12 receptor antagonist; not a prodrug and does not require hepatic activation; faster onset than prasugrel. (generic)
  11. 25. What drug (ADP receptor antagonists) is a prodrug, irreversible antagonist, slow onset of action, metabolized by hepatic esterase and CYP450 and has DDI with PPIs and CYP2C19 inhibitors? (generic name)
  12. 26. half-life for aspirin is ____ minutes (spell it out)
  13. 29. name the other PDE3 inhibitor drug that is not Dipyridamole
  14. 32. Coadministration of aspirin with _____ _______ or other urine acidifiers may lead to aspirin toxicity
Down
  1. 1. when aspirin is taken at high doses, it can ______(inhibit or active) prostacyclin production without increasing the effectiveness of the drug as an antiplatelet agent
  2. 2. aspirin is often used as an antiplatelet agent to prevent arterial thrombosis leading to TIA, stroke and MI at a dose of _____mg once daily (spell out number)
  3. 3. Abciximab, eptifibatide, tirofiban and defibrotide are ______ IIb/IIa receptor antagonists
  4. 4. class of drug that acts primarily by inhibiting platelet adhesion to the vessel wall and inhibits platelet aggregation by increasing the formation of cAMP and lowering the level of platelet calcium
  5. 5. high doses of aspirin have a direct ________effect that can increase the anticoagulant effect and thereby increase the likelihood of bleeding
  6. 8. aspirin transfers an ____ group to the enzyme to form salicylic acid
  7. 9. drug that inhibits thrombin-related platelet aggregation; antagonist at protease-activated receptor 1 (PAR-1; very long half life. (generic)
  8. 11. aspirin is used in combo with _____ for postoperative primary prophylaxis of thromboemboli in patients with prosthetic heart valve
  9. 12. stimulates platelet aggregation
  10. 15. which drug must you store in the original package, protect from moisture, and keep a desiccant in the bottle so the carbamate ester does not hydrolyze during storage? (generic)
  11. 16. What drug inhibits platelet aggregation and also prevents and treats arterial thromboembolic disorders?
  12. 19. true or false: low dose aspirin does not inhibit PGI2 synthesis effectively, but has a selective effect on TxA2 levels
  13. 20. what drug has a nucleoside triphosphate analogue and is selective and reversible oral P@y12 receptor antagonist? hint:t1/2= 3-6 min(generic)
  14. 22. Abciximab is chimeric _____ _____ monoclonal antibody and binds irreversibly.
  15. 23. drug that is a coronary vasodilator and a week antiplatelet drug
  16. 27. COX-1 inhibitor drug
  17. 28. What drug (ADP receptor antagonist) is a prodrug, irreversible antagonist, rapid onset of action, more potent, decreased polymorphism and has more bleeding risk? (generic name)
  18. 30. name the thrombin receptor (PAR-1) antagonist drug
  19. 31. aspirin can cause _____, especially in the GI tract
  20. 33. clopidogrel is metabolized by what enzyme to become active?