Anti-tumor immunity

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Across
  1. 2. Formation of new blood vessels in tumors.
  2. 4. Cytotoxic proteins released by NK and CD8+ T cells to destroy tumor cells.
  3. 6. Molecule expressed by tumors that suppresses T-cell activity.
  4. 7. Highly immunogenic mutation-derived tumor antigens
  5. 9. Immunologically active tumors rich in T-cell infiltration are called ____ tumors
  6. 11. Chronic functional state of T lymphocytes caused by persistent antigen exposure in the tumor microenvironment.
  7. 14. Infiltration Process by which activated T cells migrate into tumor tissueTherapeutic strategy that blocks PD-1 or CTLA-4 signaling pathways
  8. 15. Main function of CD8+ T cells.
Down
  1. 1. Spread of tumor cells to distant organs
  2. 3. Site where naïve T cells are activated.
  3. 5. Professional antigen-presenting cells.
  4. 8. Process by which tumor cells reduce antigen presentation to avoid recognition by CD8+ T lymphocytes.
  5. 10. Macrophage subtype associated with tumor promotion.
  6. 12. Tumor microenvironment condition caused by low oxygen concentration
  7. 13. Immune cells that can kill tumor cells without antigen-specific activation.