Antibodies

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Across
  1. 4. only class that crosses placenta,Activation and binding of complement
  2. 5. Largest of all classes, 5-10% total serum immunoglobulin, most efficient at triggering classical pathway
  3. 6. Carboxl-terminal segment of antibody that consists of a polypeptide sequence found in all chains of that type
  4. 7. Flexible portion of the heavy chain of an immunoglobulin molecule that is located between the 1st and 2nd constant regions allows molecule to bend and antigen-binding sites to operate independently
  5. 8. Extremely scarce- 0.001% of serum immunoglobulin, more susceptible to proteolysis than other classes,Found on the surface of B lymphs
  6. 11. Amino-terminal region of an immunoglobulin that has a unique aminoacid sequence and is responsible for the specificity of antibody
  7. 12. Anti-inflamitory agent,Down regulation of phagocytosis, chemotaxis, bactericidal activity, cytokine release
  8. 13. Fragment of an immunoglobulin molecule obtained by papain cleavage that consists of a light chain and 1/2 of a heavy chain held together by disulfide bonding
  9. 14. 1 of 2 light chains present in 2/3 of immunoglobulins
Down
  1. 1. 1 of 2 light chains present in 1/3 of immunoglobulins
  2. 2. Glycoprotein that links immunoglobulin monomers together, only found in IgM and IgA
  3. 3. Fragment of an immunoglobulin molecule obtained by papain cleavage that consists of the carboxyl-terminal halves of 2 heavy chains that are held together by disulfide bonds
  4. 9. One of the polypeptide units that makes up an immunoglobulin molecule
  5. 10. Small chain in an immunoglobulin molecule that is bound to larger chain by disulfide bonds
  6. 12. Least abundant - 0.0005% total serum immunoglobulin, ability to activate mast cells and basophils in allergic reactions