Antiviral Agents

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Across
  1. 5. Alanine-containing prodrug moiety found in some antiviral nucleoside analogs
  2. 7. Included in some antiviral drug combinations as a CYP3A4 inhibitor
  3. 8. 36-amino acid protein that binds to gp41 of HIV-1, preventing fusion of viral and host cell membranes
  4. 9. Anti-HIV agents that inhibit HIV protease
  5. 10. Acyclic nucleosides used to treat herpes viruses
  6. 12. Anti-HIV agents that inhibit HIV integrase
  7. 13. Direct-acting anti-hepaciviral agents that target Hep C NS5B RNA polymerase
  8. 14. Direct-acting anti-hepaciviral agents that target Hep C NS5A phosphoprotein
  9. 15. Direct-acting anti-hepaciviral agents that target Hep C NS3/4 protease
  10. 16. Anti-influenza agents that target neuraminidase
Down
  1. 1. Pyrophosphate analog that inhibits several polymerases
  2. 2. Anti-HIV agent that binds to chemokine receptor 5 (CCR5), preventing the receptor from binding to viral gp120
  3. 3. Azide (N=N=N–)-containing nucleoside reverse transcriptase inhibitor (NRTI)
  4. 4. Polyethylene glycol-modified protein that inhibits all phases of the Hep B and Hep C viral life cycle
  5. 6. Chemotype of the second-generation Non-nucleoside reverse transcriptase inhibitors (NNRTIs)
  6. 11. First-in-class HIV-1 capsid inhibitor for the treatment of multidrug-resistant HIV-1