Antivirals

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Across
  1. 1. neuraminidase inhibitors for treatment of flu prevent __________ of the virus
  2. 8. __________ resistance assays (indirect) use PCR to determine whether genes known to cause resistance are present in a sample
  3. 9. NRTIs used in HIV treatment function using __________ inhibition to cause termination of the DNA chain being built by reverse transcriptase
  4. 11. genotypic PCR testing can also be used to monitor __________ viral loads
  5. 13. __________ hybridization is a phenotypic assay that measures the effect antiviral reagents have on a virus
  6. 14. NNRTIs used in HIV treatment target a __________ binding site on the virus' reverse transcriptase
Down
  1. 2. this class of antiviral drugs prevent viral uncoating once inside the cell and are effective for influenza A infections
  2. 3. __________ resistance assays (direct) measure the actual observable viral resistance to antiviral agents, and are difficult because they requires careful viral culturing and testing
  3. 4. these inhibitors keep a virus from attaching to host cells
  4. 5. any antivirals that inhibit the synthesis of viral mRNA, as a consequence inhibit viral __________
  5. 6. viral resistance testing can be done to evaluate potential antivirals, test for cross-resistance or reactivity to certain drugs, and to determine the frequency of drug resistance __________
  6. 7. one reason to perform viral susceptibility testing would be to monitor antigenic __________ occurring in influenza viruses for surveillance
  7. 10. nucleoside and nucleotide analogue antivirals inhibit DNA __________
  8. 12. the __________ inhibition assay is a phenotypic assay that detects NA inhibition resistance in influenzas