Autonomic Drugs: Medical Terminiology

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Across
  1. 1. Determines rate of drug delivery to tissues.
  2. 4. Non-synthetic reactions (oxidation, reduction, hydrolysis).
  3. 5. Reduced salivation due to anticholinergic drugs.
  4. 9. Synthetic conjugation with glucuronic acid, sulfate, etc.
  5. 10. Pupil dilation via sympathetic stimulation or anticholinergic effect.
  6. 11. Abnormally fast heart rate due to β1 stimulation or anticholinergic effect.
  7. 13. Inhibits the parasympathetic nervous system.
  8. 16. Time required for plasma drug concentration to reduce by half.
  9. 17. Receptor responding to norepinephrine/epinephrine; regulates vascular tone.
  10. 18. Energy-dependent drug movement across membranes.
  11. 20. Mimics the effects of sympathetic nervous system activation.
  12. 22. Fainting due to hypotension or bradycardia.
  13. 23. Volume of plasma cleared of drug by kidneys per unit time.
  14. 27. Movement across membrane without energy, following concentration gradient.
  15. 29. Fraction of administered drug reaching systemic circulation.
  16. 30. Ligand-gated ion channel receptor for acetylcholine.
  17. 32. A drug that activates a receptor to produce a biological response.
  18. 33. A drug that binds to a receptor and blocks its activation.
  19. 34. G-protein-coupled receptor activated by acetylcholine.
  20. 35. Refers to drugs that mimic norepinephrine or epinephrine and stimulate sympathetic activity.
  21. 36. Enzyme family involved in oxidative metabolism of drugs.
Down
  1. 2. Inhibits the sympathetic nervous system.
  2. 3. Pupil constriction via parasympathetic stimulation.
  3. 6. Process increasing drug-metabolizing enzyme activity.
  4. 7. Liver transformation of drugs via oxidation, reduction, or conjugation.
  5. 8. Slow heart rate due to parasympathetic stimulation.
  6. 12. Drugs that block muscarinic acetylcholine receptors, inhibiting parasympathetic effects.
  7. 14. Elevated blood pressure from adrenergic overstimulation.
  8. 15. Reversible binding of drugs to albumin or α1-acid glycoprotein.
  9. 16. Low blood pressure from α-blockade or β2 activation.
  10. 19. Stimulates the parasympathetic nervous system.
  11. 21. Decrease in enzyme activity slowing drug metabolism.
  12. 24. Refers to drugs that mimic acetylcholine and stimulate parasympathetic activity.
  13. 25. Determines drug’s ability to cross membranes and BBB.
  14. 26. Hypothetical volume needed to contain total drug at same concentration as in plasma.
  15. 28. Hepatic metabolism before drug reaches systemic circulation.
  16. 31. Receptor that mediates cardiac and bronchodilatory effects.
  17. 32. Drugs that block adrenergic receptors, reducing sympathetic activity.