B Cell Development

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Across
  1. 3. Receptor that monitors the quality of the immunoglobulin heavy chain.
  2. 8. Where B cells mature
  3. 9. A subset of cell adhesion proteins on the cell surface that are considered the "molecular glue". Abbrev.
  4. 13. An inherited genetic immune system disorder of B lymphocyte differentiation that reduces the body's ability to fight infection. Abbrev.
  5. 14. Where B cells develop
  6. 16. Tolerance induced to antigens outside the bone marrow
  7. 17. Stage of B cell development defined by heavy chain VDJ gene segment rearrangement
  8. 18. Way of modifying antigen receptors of autoreactive immature B cells
  9. 19. Immunological tolerance induced in a primary lymphoid organ; the bone marrow in the case of B cells
  10. 20. Type of B cell that moves from the bone marrow to the spleen
Down
  1. 1. Large lymphoid organ in the upper left part of the abdomen where the responses of lymphocytes to blood borne pathogens are made
  2. 2. The first chain that rearranges in B cell development
  3. 4. Innate lymphocyte subset that arises in early B cell development and are present only in low numbers in secondary lymphoid organs
  4. 5. Stage of B cell development defined by light chain VJ gene segment rearrangement
  5. 6. Minor population of B cells in the spleen
  6. 7. Majority of peripheral B cells that reside in the spleen and other secondary lymphoid organs
  7. 10. Programmed cell death
  8. 11. Cell that is defined by light chain gene rearrangement and expression of IgM.
  9. 12. Type of cells that can differentiate into many different cell types
  10. 15. Phenomenon that occurs when a cell expresses only one of its two copies of a gene