BHS 316 immunology chapter 2 vocab

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Across
  1. 6. (1 word) C3bBb functions as this type of enzyme in the complement alternative activation pathway. In the MBL activation pathway, MASP functions as this type of enzyme.
  2. 11. (1 word) The _________ system is a part of the innate immune system that ultimately leads to a membrane attack complex punching holes in invaders.
  3. 12. (1 word) This type of molecule is abundant on gram-negative bacteria cell walls.
  4. 15. (1 word) One of three levels of macrophage readiness. At this level, macrophages secrete TNF, and become very large and phagocytic.
  5. 16. (1 word) Macrophages and neutrophils are considered professional __________.
  6. 18. (1 word) When they detect a virus, plasmacytoid dendritic cells become _______ factories.
  7. 19. (1 word) This protein is pre-made in neutrophils. When it binds to its binding partner on endothelial cells, the neutrophil stops rolling along the blood vessel.
  8. 20. (1 word) The complement system activation pathway that is antibody-dependent.
  9. 21. (2 words) This class of molecular patterns are released by cells that died due to infection.
Down
  1. 1. (1 word) A sugar type that is common on the surface of pathogens but not human cells. Important for one of the cascade activation pathways.
  2. 2. (2 words) This immune cell is short-lived and can kill invading or tumor cells by using the protein perforin to deliver “suicide” enzymes
  3. 3. (1 acronym) This adhesion protein is constitutively expressed on endothelial cells of the blood vessels.
  4. 4. (3 words) Forms during the complement cascade and is made up of complement proteins C5b, C6, C7, C8, C9.
  5. 5. (1 word) The most common type of leukocyte. They are short-lived and are “on-call” from the blood.
  6. 7. (2 words) This is one of the chemoattractants, along with C5a, that neutrophils “sniff” out as they leave the blood to locate the site of inflammation.
  7. 8. (1 word) This protein is expressed on endothelial cells which, when bound to its partner, slows the rolling of neutrophils within blood vessels.
  8. 9. (2 words) Immune cells come with this type of receptor so that they can broadly recognize many classes of microbes.
  9. 10. (2 words) This class of molecular patterns can be found on many types of invaders.
  10. 13. (2 words) This protein is constitutively expressed on the surface of neutrophils.
  11. 14. (1 word) The organ where most complement proteins are produced.
  12. 16. (1 word) One of three levels of macrophage readiness. This level occurs in response to IFN-γ secretions from helper T cells and natural killer cells. Class II MHC molecules are upregulated, and the macrophage becomes more phagocytic.
  13. 17. (1 word) One of three levels of macrophage readiness. At this level, macrophages primarily clean up cellular debris and dead cells. They present few class II MHC molecules.