Biologics for autoimmune disease

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Across
  1. 5. I was trialled as a treatment for cytokine release syndrome in severe COVID-19
  2. 9. I am handy if you want to block the effects of IL-12 and IL-23 at the same time
  3. 10. I am sometimes called ‘Vitamin R’
  4. 11. I am the first therapeutic antibody developed using phage display technology
  5. 12. I am sometimes functionally confused with the anti-CTLA-4 blocking antibody ipilimumab
Down
  1. 1. My use in Crohn’s Disease worsened the outcome for many patients
  2. 2. I can be used to stop lymphocytes moving around in the treatment of Crohn’s disease
  3. 3. I was dangerously close to being ‘shelved’ for my role in reactivating the deadly John Cunningham virus
  4. 4. I am a humanized antibody originally developed to treat leukemia, but now also used to deplete lymphocytes in MS
  5. 6. I am a ‘pegylated’ Fab fragment used to block TNF
  6. 7. I am a chimeric antibody used to block TNF
  7. 8. I am used as a decoy receptor for TNF
  8. 13. As an antibody that affects B cells, I have been more successful in treating SLE than Rituximab