Biomarkers in MS

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Across
  1. 2. Imaging technique used to identify lesions and volume loss
  2. 4. Biomarker frequently assessed from bodily fluids
  3. 6. Imaging method for observing spinal cord lesions
  4. 7. located largely within the hippocampus and frontal lobes
  5. 10. May predict conversion from CIS to MS
  6. 11. May help inform treatment course
  7. 13. Measures degeneration of the optic nerve
  8. 15. Used to identify at-risk individuals
  9. 16. Structural protein in axons
  10. 17. Characterized by inflammatory demyelination, remyelination failure, and axonal degeneration
Down
  1. 1. Popular imaging biomarker used to diagnose MS and evaluate disease activity
  2. 3. Up to 90% of patients with MS have these in the CSF
  3. 5. Helps differentiate between diseases
  4. 8. Biomarker used to complement clinical assessments
  5. 9. Used to evaluate the presence of OCB
  6. 10. Intermediate filament found in astrocytes, associated with higher T2 lesion load
  7. 12. may quantitatively evaluate microglial activation within NAWM
  8. 14. could identify threat of treatment failure