Biopharmaceutics Crossword Puzzle

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Across
  1. 6. Process where solid drug particles dissolve in gastrointestinal fluids.
  2. 7. Ability of a drug to cross biological membranes.
  3. 8. Fraction of an administered drug reaching systemic circulation unchanged.
  4. 9. Movement of drug from site of administration into bloodstream.
  5. 10. Removal of drug and metabolites through urine, bile, or feces.
Down
  1. 1. Volume of plasma cleared of drug per unit time.
  2. 2. Reversible transfer of drug from blood to body tissues.
  3. 3. Time required for plasma drug concentration to decrease by fifty percent.
  4. 4. Biotransformation of drugs mainly occurring in the liver.
  5. 5. Hepatic metabolism reducing drug concentration before systemic circulation.