Biotherapies

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Across
  1. 2. Any foreign material that can stimulate an immune response and be bound by specific antibody or specific lymphocytes.
  2. 4. Term to describe derived from the same individual.
  3. 5. General name for products that include cellular immunotherapies, cancer vaccines, and other types of both autologous and allogeneic cells for certain therapeutic indications, including hematopoetic stem cells and adult and embryonic stem cells.
  4. 8. Term used to describe the formation of blood cellular components.
  5. 11. These types of products include cellular immunotherapies, cancer vaccines, and other types of both autologous and allogeneic cells for certain therapeutic indications, including hematopoietic stem cells and adult and embryonic stem cells.
  6. 12. Term to denote donor and intended recipient are different individuals.
  7. 14. International, not-for-profit Association representing individuals and institutions involved in the fields of transfusion medicine and biotherapies. Committed to improving health through the development and delivery of standards, accreditation and educational programs that focus on optimizing patient and donor care and safety.
  8. 17. A type of treatment that seeks to modify or manipulate the expression of a gene or to alter the biological properties of living cells for therapeutic use.
  9. 18. Specific type of cell capable of evolving into many different types of specialized cells within the body. There are three primary types of stem cells: embryonic stem cells (characterized as pluripotent in nature—capable of developing into the two hundred or so specialized cells of the adult organism); adult stem cells (exist within certain tissues of the body (e.g., blood and bone marrow) and carry out repair and regenerative functions); and induced pluripotent stem cells (iPSCs) (adult stem cells that have been genetically reprogrammed to behave like embryonic stem cells).
  10. 21. Substance that remains in the placenta and in the attached umbilical cord after childbirth. It is collected because it contains stem cells, which can be used to treat hematopoietic and genetic disorders such as cancer.
Down
  1. 1. A type of treatment that uses substances made from living organisms to treat disease. Substances may occur naturally in the body or be made in the laboratory.
  2. 3. Abbreviation for hematopoietic stem cell which is a type of cell giving rise to other blood cells in a process called hematopoiesis.
  3. 6. Process of removing a specific component of the blood, such as platelets, red blood cells, plasma (liquid part of the blood) or granulocytes (white blood cells) and returning the remaining components to the donor--- allowing more of one part of the blood to be collected than could be separated from a unit of whole blood.
  4. 7. The branch of medicine that develops methods to regrow, repair or replace damaged or diseased cells, organs or tissues.
  5. 9. Abbreviation for mesenchymal stromal cells which are multipotent adult stem cells present in multiple tissues, including umbilical cord, bone marrow and fat tissue. Mesenchymal stem cells can self-renew by dividing and can differentiate into multiple tissues including bone, cartilage, muscle and fat cells, and connective tissue. Several possibilities for their clinical use include in bone/cartilage repair, heart/blood vessel repair and inflammation and autoimmune disease.
  6. 10. A U.S. agency responsible for protecting the public health by ensuring the safety, efficacy, and security of human and veterinary drugs, biological products, and medical devices; and by ensuring the safety of the nation's food supply, cosmetics, and products that emit radiation.
  7. 13. A four-letter abbreviation that accompanies 128 which is the global standard for the terminology, identification, coding and labeling of medical products of human origin (including blood, cell, tissue, milk, and organ products). It is used in more than 87 countries across six continents and disparate health care systems.
  8. 15. Soft spongy tissue in the body, found in the center of most bones, that contains hematopoietic stem cells (HSC). (HSC are also found in blood moving throughout your body).
  9. 16. Abbreviation for chimeric antigen receptor T-cell. A type of treatment in which a patient's T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion. CAR T-cell therapy is used to treat certain blood cancers, and it is being studied in the treatment of other types of cancer.
  10. 19. Abbreviation for term to describe when cells from a donated stem cell graft attack the normal tissue of the transplant patient (hint: graft vs host disease)
  11. 20. Substance that consists of a fluid (plasma) containing cells (erythrocytes, leucocytes, and platelets)