Case 6

12345678910111213141516171819202122232425
Across
  1. 3. Basic contractile unit of striated muscle
  2. 5. Tumor of the thymus commonly associated with myasthenia gravis
  3. 7. First-line drug for Lambert-Eaton syndrome
  4. 9. Diagnostic test measuring electrical activity of muscles
  5. 10. Neurotransmitter released at the neuromuscular junction
  6. 11. Visible muscle twitches seen in lower motor neuron disease
  7. 14. Protein that binds calcium to initiate muscle contraction
  8. 16. Sarcoplasmic reticulum channel/receptor that releases calcium
  9. 18. First-line acetylcholinesterase inhibitor used in MG treatment
  10. 20. Enzyme that breaks down acetylcholine in the synaptic cleft
  11. 21. Type of lung cancer malignancy most often associated with Lambert-Eaton syndrome
  12. 23. G-protein coupled receptor activated by acetylcholine in parasympathetic targets
  13. 24. Irreversible acetylcholinesterase inhibitor that can cause cholinergic crisis
  14. 25. Drooping eyelid commonly seen in MG
Down
  1. 1. Site where motor neuron communicates with skeletal muscle
  2. 2. Autoimmune disease with antibodies against nicotinic acetylcholine receptors
  3. 4. Autoimmune disorder with antibodies against presynaptic calcium channels
  4. 6. Protein linking actin to the extracellular matrix, defective in Duchenne muscular dystrophy
  5. 8. Therapy removing circulating antibodies during myasthenic crisis
  6. 12. Ligand-gated ion channel activated by acetylcholine at the NMJ
  7. 13. Toxin that blocks acetylcholine release causing flaccid paralysis
  8. 15. Muscle enzyme elevated in myopathies
  9. 17. Antimuscarinic drug used to treat organophosphate poisoning
  10. 19. Insulating sheath that speeds nerve conduction
  11. 22. Dysfunction such as dry mouth commonly seen in Lambert-Eaton syndrome