cats

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Across
  1. 1. Too much stimulation and receptors stop responding normally
  2. 5. Bind elsewhere and modify signalling
  3. 9. Converts ATP into signalling molecules
  4. 10. When gentle touch becomes painful
  5. 12. When vessels need to tighten dramatically this peptide speaks
  6. 14. After kinases mark receptors I take over
  7. 15. Platelets use me to encourage clotting and constriction
  8. 17. Shift sideways and I change
  9. 18. Full response without full occupancy depends on me
  10. 20. Immune signals coordinating inflammation
  11. 22. Heavenly messenger that travels backward across synapses to quiet release
  12. 23. Chronic agonist exposure reduces receptor numbers through me
  13. 24. Calcium binds me before contraction begins
  14. 25. Opposite of thromboxane in both clotting and vessel tone
Down
  1. 2. Cholera toxin turns these cells into fluid pumps
  2. 3. Quiet constitutive receptors below baseline activity
  3. 4. Opposes kinase driven contraction
  4. 6. Bind where the natural ligand belongs
  5. 7. Smooth muscle movement depends on me
  6. 8. Asthmatics often suffer when too much of me appears
  7. 11. Receptors disappear from the surface but may return later
  8. 13. Radical messenger that relaxes vessels
  9. 16. Cholera toxin overstimulates this enzyme
  10. 19. Lower the ceiling and I change
  11. 21. Receptors and signalling proteins lose communication through me