CCB/Amlodipine(Norvasc)

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Across
  1. 7. Reflex increase in heart rate sometimes seen in potent vasodilators.
  2. 9. Peripheral vasospastic condition that can improve with dihydropyridine CCB’s.
  3. 10. Primary vascular bed dilated by dihydropyridine CCB’s.
  4. 12. Typical dose adjustment strategy based on BP response and tolerability.
  5. 13. Amlodipine has a gradual start of action compared with short acting DHP’s.
Down
  1. 1. Dihydropyridine calcium channel blocker indicated for hypertension and angina.
  2. 2. Dose caution scenario often monitored due to comorbidities; consider slower titration in organ dysfunction.
  3. 3. Structural subclass of Calcium Channel Blockers that primarily target vascular smooth muscle L-type channels.
  4. 4. Sodium and fluid _____; may contribute to edema when arteriolar vasodilation is unopposed.
  5. 5. Amlodipine reduces calcium influx through L-type channels, decreasing peripheral resistance.
  6. 6. Common adverse effect of dihydropyridine CCB’s due to precapillary arteriolar dilation.
  7. 8. Amlodipine’s effective duration supports once-daily dosing.
  8. 11. CyP3A4 inhibitors can increase exposure; inducers may reduce effect- monitor clinically.