Cell Metabolism

2. A central cellular respiration pathway, produces NADH and FADH2, occurs in the mitochondria
4. The ______ effect; tumor cell reliance on glycolysis rather than oxidation to meet metabolic needs
5. By-products of normal oxygen metabolism; can cause irreversible damage to DNA
7. any metabolic process that involves the breakdown of complex molecules (such as proteins or lipids) and the release of energy
10. Key part of an important TCA cycle intermediate; consists of a β-mercaptoethylamine group linked to the vitamin pantothenic acid (B5) through an amide linkage[3] and 3'-phosphorylated ADP
11. term applied to particular biochemical pathways in which metabolites are newly biosynthesized
13. abbreviation for an essential metabolite; methyl group donor involved in the methylation of DNA, RNA and histones
15. major eukaryotic lipid, named after a legendary mythological creature that creates riddles
16. most abundant free amino acid in circulation; very important in cancer metabolism

1. serine/threonine kinase; interacts with Akt, a key player in mammalian metabolism
3. State of scarcity of a metabolite, like glucose
6. Term employed to describe a cellular system used to translocate electrons across impermeable membranes
8. endogenous intermediates of metabolism that aberrantly accumulate in cancer cells
9. final step of cellular respiration; a series of redox reactions involving the flow of electrons along a series of membrane-bound proteins, coupled with the generation of Adenosine triphosphate (ATP)
12. electron donating molecule; used by enzymes to synthesize large biomolecules
14. deprivation of oxygen, can drive tumor progression