Chapter 10, Fei Monkelbaan

3. - Cellular environment where viruses replicate, making it difficult to target the virus without damaging human tissue
4. - The ratio of the dose of a drug that is toxic to humans compared to its minimum effective dose
6. - Property describing how easily a drug can be taken by or given to a patient (e.g., oral vs. IV)
8. - Desirable drug property where an antimicrobial harms the microbe without damaging host tissues
9. - Antimicrobial property that is LOW or POOR when a drug targets structures (like double-stranded DNA or plasma membranes) shared by both pathogen and human host
10. - Use of a drug to prevent infection of a person at risk
12. - Naturally occurring antimicrobial compounds originally produced as secondary metabolic products of bacteria and fungi
15. - All-inclusive term for any antimicrobial drug, regardless of its origin
16. - Cell type shared by both humans and fungi, limiting the number of unique drug targets for treatment
17. - Bacteriophage-encoded enzymes that degrade the bacterial cell wall peptidoglycan, causing rapid cell lysis and death

1. - Bacterial immune system used as a genome editing tool to make targeted cuts in double-stranded DNA resistance genes
2. - Viruses that specifically infect and lyse bacterial cells, historically displaced by the advent of antibiotic treatments
5. - Ability of a drug to travel through body tissues to reach deep infection site
7. - Category of antimicrobial drugs that are isolated from natural biological sources and then chemically modified in the laboratory
11. - Reason pharmaceutical companies slow down antibiotic innovation: short treatment courses and low return on investment make them financially non
13. - Mechanism by which bacteria survive antimicrobial drugs through active transport pumps, chemical destruction, or modified binding sites
14. - Complex, matrix-enclosed community of microbes that relies on quorum sensing to establish and maintain structure