Chapter 12 Crossword Puzzle

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Across
  1. 3. process by which the affinity of antibodies produced in response to a protein antigen increases with prolonged or repeated exposure to that antigen
  2. 6. enzyme involved in isotype switching
  3. 9. immunoglobulin molecule (or BCR type) on a naïve B cell to which an antigen binds
  4. 12. foci or area where initial T and B cell interactions occur during antigen exposure
  5. 13. mechanism that leads to affinity maturation
  6. 15. type of antibody that is generated during parasitic infections
Down
  1. 1. the region of the follicle containing proliferating B cells
  2. 2. the molecular mechanism of isotype switching
  3. 4. nature of antigen that generates antibody response with the help of T cells
  4. 5. ligand present on T cells that help in proliferation of antigen-specific B cells
  5. 7. B cells located in the peripheral region of the splenic white pulp (no need to write ‘B cells’)
  6. 8. B cells that make the bulk of T-dependent, class-switched, and high-affinity antibody responses to protein antigens (no need to write ‘B cells’)
  7. 10. cells that are activated B cells and most likely are progeny of isotype-switched high-affinity B cells but do not differentiate into active antibody secretors (no need to write the word ‘cells’)
  8. 11. process by which some B cells differentiate and produce different heavy chain isotypes
  9. 14. CD4+ T cells that migrate into B cell–rich follicles (abbreviation, no need to write ‘cells’)