chapter 14 - Disorders In Immunity

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Across
  1. 5. autoantibodies form immune complexes that bind to the membrane of joints, activating cytokine release by macrophages ; chronic inflammation develops, leading to scar tissue and joint destruction
  2. 7. allergy and autoimmunity ; tissues are attacked by immune components that can’t distinguish one’s own tissues from foreign material
  3. 8. A healthy and diverse microbiome is important to “train” our immune system what to react against and what to tolerate
  4. 13. this is lupus and is characteristic butterfly-shaped rash
  5. 14. systemic, sometimes fatal, reaction that involves airway obstruction and circulatory collapse
  6. 15. this type of Hypersensitivity activates IgG- & IgM-mediated cell damage
  7. 16. allergies that enter through the skin
  8. 18. enty through: the respiratory tract, the gastrointestinal tract, the skin.
  9. 19. SCID ; involve dysfunction in both lymphocyte systems – B and T cells
Down
  1. 1. The industrialized world has created a hygienic environment; antimicrobial substances, well-insulated homes
  2. 2. controlled exposure to the antigen through ingestion, sublingual absorption, or injection to reset the allergic reaction
  3. 3. Atopy (Type I Hypersensitivity)episodes of impaired breathing due to severe bronchoconstriction
  4. 4. clicking, bubbling, or rattling sounds in the lungs
  5. 6. immunodeficiency ; the immune system is incompletely developed, suppressed, or destroyed
  6. 9. this type of Hypersensitivity activates immune complexes
  7. 10. Graft versus host disease; graft attacks any host tissue bearing foreign MHC markers, instead of the host rejecting the graft
  8. 11. Acute Post-Streptococcal Glomerulonephritis
  9. 12. the study of disease states associated with the overreactivity or underreactivity of the immune response
  10. 17. chronic localized allergy such as hay fever or asthma