Chapter 8 Crossword Puzzle

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Across
  1. 4. the process by which lymphocyte progenitors in the thymus and bone marrow differentiate into mature lymphocytes
  2. 6. process because of which each B cell can express an Ig heavy chain from only one of the two inherited parental alleles
  3. 10. enzymes that remove nucleotides from V, D, and J gene segments at the sites of recombination
  4. 12. lymphoid-specific enzyme that is essential for the somatic recombination of V and J, or of V, D, and J, gene segments
  5. 14. receptor responsible for greatest proliferation of developing lymphocytes
  6. 15. selection facilitating the survival of potentially useful lymphocytes (no need to write the word ‘selection’)
Down
  1. 1. tolerance that is developed in the generative lymphoid organs (no need to write the word ‘tolerance’)
  2. 2. hematopoietic stem cells mature into these cells and then these cells give rise to B cells, T cells, and innate lymphoid cells
  3. 3. name of the process by which developing T or B cells are eliminated if they bind with high affinity to self-antigens.
  4. 5. transcription factor for T cell maturation (no need to include hyphen)
  5. 7. t cells that are the least developed progenitors in the thymus
  6. 8. last name of the scientist who elucidated the mechanism for B- and T-cell receptor diversity
  7. 9. organ responsible for B-1 cells in a fetus
  8. 11. events that preserve cells that have produced functional antigen receptor proteins and eliminate potentially dangerous cells (no need to include the word ‘events’)
  9. 13. gene segment that only occurs in the Ig heavy-chain and TCR β-chain loci