CHI Lab Week 2026 Crossword 3

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Across
  1. 3. Short DNA sequence ligated to fragments for sequencing library preparation.
  2. 5. Non-coding region of a gene, spliced out during mRNA processing.
  3. 6. Bioinformatics process of removing low-quality bases or adapters from reads.
  4. 8. Abbreviation for the proportion of sequencing reads supporting a variant.
  5. 10. Bioinformatics tool that maps sequencing reads to a reference genome.
  6. 12. Step in nucleic acid extraction where cell membranes are disrupted.
  7. 14. Step in extraction where purified nucleic acids are separated from the matrix.
  8. 15. Abbreviation for procedures ensuring data and sample integrity.
  9. 16. File format specifying genomic intervals for analysis.
  10. 18. Series of bioinformatics steps for processing sequencing data.
  11. 19. Coding region of a gene that remains in mature mRNA.
  12. 20. Basic dye that stains cell nuclei blue in histology.
Down
  1. 1. General term for a difference in DNA sequence compared to a reference.
  2. 2. Type of mutation acquired in non-germline cells, often relevant in cancer.
  3. 4. Wax used to embed tissue samples for sectioning in histology.
  4. 7. Instrument used to cut thin tissue sections for microscopic examination.
  5. 9. File format storing both nucleotide sequences and quality scores in NGS.
  6. 11. Adding functional or clinical information to identified genetic variants.
  7. 13. Abbreviation for a single nucleotide change in the genome.
  8. 17. Process of removing embedding medium before staining tissue sections.