Chromosomal Structure and Mutations

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Across
  1. 1. cytogenic probe analysis designed to visualize the entire complement of metaphase chromosomes, with unique colors for each chromosome
  2. 5. probes that bind to telomeres
  3. 9. FISH probes designed to detect translocations where there are multiple possible partners
  4. 11. a type of mutation involving alterations in the number of chromosomes
  5. 12. type of translocation involving movement of most of one entire chromosome to the centromere of another chromosome
  6. 13. array of intact chromosomes displayed upon hypotonic lysis of a nucleus
  7. 14. probes that bind to centromeres
  8. 16. a difference in DNA sequence found in less than 1% of the population
  9. 20. FISH probes designed to detect translocations and their reciprocal products
  10. 21. having 3 of each chromosome
Down
  1. 2. a complete set of metaphase chromosomes of a cell
  2. 3. a type of mutation involving alterations in the primary DNA sequence
  3. 4. abnormal chromosome comprissed of rearranged parts from two or more unidentified chromosomes joined to a normal chromosome
  4. 6. a type of mutation involving structural changes in chromosomes
  5. 7. a difference in DNA sequence found in more than 1% of the population
  6. 8. pattern on chromosomes after staining with Giemsa
  7. 10. type of inversion including the centromere
  8. 14. method to deletions or amplifications in DNA
  9. 15. type of translocation involving the exchange of DNA between separate chromosomes with no gain or loss of genetic material
  10. 17. introchromosomal breakage, reversal and reunion of genetic material
  11. 18. basic protein that associates with DNA during compaction
  12. 19. having an aberrant number of chromosomes per nucleus