Cystic Fibrosis

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Across
  1. 1. CF can affect bone ___ leading to osteoporosis
  2. 4. The only anti-inflammatory drug recommended for CF patients
  3. 5. Pulmonary exacerbations are worsened by ____
  4. 11. Patients with end-stage lung disease may require a lung ___
  5. 13. Pathogens are cleared through the mucociliary ___
  6. 16. There is a hyper-concentration of ___ in the respiratory system
  7. 21. Neutrophil ___ can be detected early in infants with CF
  8. 22. Concentrations of this metabolite increase apoptosis and inflammation
  9. 24. A lack of pancreatic ___ impacts digestion
  10. 25. Pathogens trigger an _____ response in the lungs
  11. 28. CF is diagnosed in this age range
  12. 29. These drugs increase CFTR production
  13. 30. Inflammation in the CF lung is ___ because it involves many pathways
  14. 33. CFTR is a transport _____
  15. 35. The chloride channel opens when it is ___ by protein kinase A
  16. 36. First corrector drug discovered
  17. 37. CF related diabetes can be treated with ____
  18. 39. CF is an autosomal _____ disease
  19. 40. CF mainly affects this race
  20. 41. Carriers of the disease are ____
  21. 42. ___ stress suppresses CFTR function
  22. 44. Neutrophils produce serine ___ which degrade CFTR
  23. 45. Stabilizers prevent CFTR ____
  24. 47. The earliest sign of lung disease in CF patients is ___
Down
  1. 2. These factors are responsible for upregulating the airway inflammatory response in CF patients
  2. 3. CF can cause mortality due to failure of this system
  3. 6. Cells impacted in the respiratory, GI, and reproductive tracts
  4. 7. The most common respiratory pathogen in CF patients is staphylococcus ___
  5. 8. Substance responsible for expansion and solubilization of mucin
  6. 9. Effect of CF on reproductive system
  7. 10. Increased sweating may result in ____
  8. 12. In CF patients, the airway surface is more __ than normal
  9. 14. The ion channel is ____ dependent
  10. 15. Kinds of cells which secrete mucus
  11. 17. This amino acid is deleted in mutated genes
  12. 18. Type of glands impacted
  13. 19. This type of immune cell is recruited first during inflammation
  14. 20. Neonatal screenings of the disease look at levels of serum ____
  15. 23. Forced expiratory ___ detects disease progression
  16. 26. This acid is highly expressed in the cell membranes of CF patients
  17. 27. Some drugs used to treat CF are CYP3A ___
  18. 28. These kinds of channels are not expressed properly
  19. 30. In Class II CFTR mutations, the protein is ____
  20. 31. Elevated __ levels in sweat are used as a diagnostic indicator
  21. 32. Process which take place in the distal tubules of sweat glands
  22. 34. CFTR deficiency affects ___ pressure
  23. 38. Mucins are packaged as ___
  24. 43. A rare complication of CF is chronic ____
  25. 45. CF patients have glutathione ___ which can lead to inflammation
  26. 46. The use of ___ saline helps a CF patient to expectorate