Cystic fibrosis and bronchiectasis

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Across
  1. 4. due to obstruction of airways with viscid mucopurulent material and associated with areas of collapse
  2. 5. have a high concentration of CFTR
  3. 7. one of the basic mechanisms of pathophysiology behind bronchiectasis, e.g. a condition with decreased ciliary beat frequency
  4. 12. the defective protein produced by the gene in CF
  5. 14. symptoms include bowel obstruction with dehydration
  6. 16. frequent oily offensive stools
  7. 17. diagnostic test for cystic fibrosis
  8. 18. leads to pulmonary hypertension
  9. 19. effective, an essential part of ACT,
Down
  1. 1. CF requires high kilojoule, high fat diet
  2. 2. coughing up of blood, advanced disease clinical presentation
  3. 3. inherited as an autosomal recessive trait
  4. 6. characterised by irreversible dilation of the bronchial tree, affects different lobes with different conditions
  5. 7. one of the basic mechanisms of pathophysiology behind bronchiectasis, e.g. mycobacterium tuberculosis, repeated chest infections secondary to GOR
  6. 8. excessive, causing water to be drawn into cell
  7. 9. one of the basic mechanisms of pathophysiology behind bronchiectasis, e.g. tumour, foreign body
  8. 10. apical membrane surfaces have a high concentration of CFTR
  9. 11. symptoms include impaired mucociliary clearance
  10. 13. pre-natal screening using chorionic villus sample
  11. 15. gastro-oesphageal reflux