Disorders in Immunity (BIO 202 Ch. 14)

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Across
  1. 4. Autoantibodies against organs, tissues, intracellular materials, caused by viral infection and loss of normal immune response suppression
  2. 5. Type of hypersensitivity involving Rh or other blood antigens
  3. 6. Type of hypersensitivity involving reaction of soluble antigen with antibody, and deposition of resulting complexes in various tissues
  4. 8. Released by mast cells in response to IgE binding during type 1 allergic response
  5. 11. When Group A Strep antibody/antigen complex settles in kidney, complement activation leads to infiltration of neutrophils, kidney damage results
  6. 14. The study of disease states associated with over-reactivity or under-reactivity of the immune response
  7. 15. Binds to mast cells during type 1 allergy
Down
  1. 1. Weakened immune response that results in recurrent, overwhelming infections by opportunistic microbes
  2. 2. Granulocyte involved in helminth response, stimulated by histamine to release cytokines
  3. 3. Chronic localized allergy like hay fever or asthma (aka allergic rhinitis)
  4. 7. Most profuse and fast-acting allergic mediator, constricts small bronchi and dilates blood vessels, stimulates eosinophils to release inflammatory cytokines
  5. 9. A swift reaction to allergens, sudden and massive release of chemicals into tissues and blood
  6. 10. Graft attacks host tissue bearing foreign MHC markers, occurs within 100-300 days of graft
  7. 12. Type of hypersensitivity, "delayed", involves T-cells, they respond to transplanted foreign cells
  8. 13. clicking, bubbling, or rattling sounds in lungs as a result of asthma