Drug Discovery Puzzle Adventure

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Across
  1. 5. Decreases sympathetic effects by blocking β receptors
  2. 7. The fraction of an administered dose that reaches systemic circulation
  3. 11. Drugs that block renin activity to reduce angiotensin II formation and lower blood pressure.
  4. 12. replacement Replacing one functional group with another that gives similar biological activity
  5. 13. Protein containing heme groups that carry out oxygen transport or redox reactions
  6. 14. where a cell decreases the number of its receptors
Down
  1. 1. Metabolic removal of an alkyl group from oxygen, producing an alcohol and an aldehyde/ketone
  2. 2. A bulky group shields a functional group from metabolism or degradation
  3. 3. a chemical that increases the rate of urine formation
  4. 4. measure of the maximum biological effect that a drug can produce
  5. 6. Adding bulky groups to protect functional groups from degradation
  6. 8. Cellular receptors that respond to catecholamines; classified into a (alpha) and ß (beta) subtypes
  7. 9. chemical phenomenon in which a molecule shifts between two interconvertible structural
  8. 10. Altering the ring system to improve metabolic stability