Ethanol Things

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Across
  1. 3. Most ____ enters the bloodstream and is activated in muscle and other tissues to be used for energy in the TCA cycle or fatty acid synthesis
  2. 5. Oxidation of ethanol, acetaldehyde, and acetate results in a large increase of ___ in the liver
  3. 6. Pyruvate Dehydrogenase catalyzes the _____ of pyruvate to acetylcoA, a substrate in the TCA cycle
  4. 10. Formic acid is toxic to mitochondria in optic nerve cells, inhibiting axonal transport by inhibiting ______
  5. 11. Acts as a cofactor for Pyruvate Dehydrogenase
  6. 12. The brain cannot use _____ for energy if Vitamin B1 is depleted
  7. 13. Formic acid causes ______ of optic nerve cells
Down
  1. 1. The second step of ethanol metabolism is the oxidation and detoxification of acetaldehyde to acetate (by aldehyde dehydrogenase), which occurs in the
  2. 2. Is turned off due to depletion of pyruvate (shunted to lactate) and oxaloacetate (shunted to malate) because of (5 across) accumulating in the liver
  3. 4. Using alcohol while being malnourished can lead to
  4. 7. This process cannot occur without Vitamin B1. It will cause neuronal cell death (Wernicke's Encephalopathy)
  5. 8. Fomepizole is a competitive inhibitor of Alcohol Dehydrogenase (what is the abbreviation?), preventing toxic formic acid formation
  6. 9. Ethanol and methanol are metabolized into