Exam 2 Review

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Across
  1. 4. a protein on the surface of a target cell which, when ligated by a FasL protein on a killer cell, can instruct the target cell to commit suicide
  2. 8. activation of many B cells with different specificities
  3. 9. an area in the secondary lymphoid organ in which B cells proliferate, undergo somatic hypermutation, and switch classes
  4. 10. the region of the antigen that is recognized by a B or T cell's receptors
  5. 11. a synonym for positive selection. Survival in the thymus is restricted to T cells whose receptors recognize MHC-self antigen complexes
  6. 13. a process by which starved cells recycle their components
  7. 14. cluster together
  8. 15. a molecule that binds to a receptor
Down
  1. 1. synonym for central tolerance induction. The selection of T cells whose receptors do not recognize MHC-self peptide complexes in the thymus.\
  2. 2. a multi-protein complex in the cell that chops up proteins into small pieces
  3. 3. tiny tubes which transport antigen within lymph nodes
  4. 5. a cell that crowns a Peyer's patch, and which specializes in sampling antigen from the intestine
  5. 6. the process by which B cells in the bone marrow can draw again from the deck to try to make a BCR that is not self-reactive
  6. 7. an enzyme which CTLs and NK cells use to destroy their targets
  7. 8. a small molecule used by CTLs and NK cells to help destroy their targets
  8. 12. a small protein which occupies the binding groove of a class II MHC molecule until it is replaced by an exogenous peptide