Exam 2 Review

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Across
  1. 2. antibody that defends against parasites and causes anaphylactic shock
  2. 4. cells/These cells are known to function as the "brains" of the immune system
  3. 7. cells have the ability to _______ when activated
  4. 10. cells that have never been activated by encountering their cognate antigen
  5. 14. switching/B cell changes the class of antibody it produces
  6. 17. cellular protein that catalyzes the release of CLIP and allows an exogenous protein to be loaded into the groove of the class II MHC molecule
  7. 19. chippers that cut up proteins into peptides
  8. 20. helper T cells that remain "unbiased" when they are first activated
  9. 21. transporter proteins involved in MHC molecule presentation
  10. 24. tiny region of the cognate antigen that a B cell receptor actually binds to is called its _______
  11. 25. factor that stimulates the proliferation of helper T cells, and growth factor for B cells
Down
  1. 1. selection/the process of testing T cells for MHC restriction- "Do you have receptors on that recognize one of the self MHC molecules which I am expressing on my surface?"
  2. 3. order of choice of gene segments by recombination
  3. 5. T cells generally express the _____ co-receptor
  4. 6. produced by helper T cells that "recharges" NK cells
  5. 8. selection/referred to as the second test to test for tolerance of self
  6. 9. many BCRs are brought close together on the B cell surface; this is needed to generate an activation signal
  7. 11. main antibody class that guards the mucosal surfaces of the body
  8. 12. main antibody produced when a virgin B cell gets first activated
  9. 13. that encourages B cells to produce IgA antibodies
  10. 15. hypermutation/The rearranged genes for the BCR can mutate to increase the affinity of the BCRs for their cognate antigen
  11. 16. eating"
  12. 18. positive/T cells that express both CD4 and CD8 co-receptor molecules
  13. 22. chain/This molecule sits in the groove of the MHC II molecule and keeps it from picking up other peptides in the endoplasmic reticulum
  14. 23. T cells generally express the _____ co-receptor