Exam 2 Review

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Across
  1. 7. positive/T cells that express both CD4 and CD8 co-receptor molecules
  2. 8. eating"
  3. 11. T cells generally express the _____ co-receptor
  4. 12. main antibody produced when a virgin B cell gets first activated
  5. 13. tiny region of the cognate antigen that a B cell receptor actually binds to is called its _______
  6. 16. T cells generally express the _____ co-receptor
  7. 17. factor that stimulates the proliferation of helper T cells, and growth factor for B cells
  8. 19. many BCRs are brought close together on the B cell surface; this is needed to generate an activation signal
  9. 21. switching/B cell changes the class of antibody it produces
  10. 22. cells that have never been activated by encountering their cognate antigen
  11. 24. chain/This molecule sits in the groove of the MHC II molecule and keeps it from picking up other peptides in the endoplasmic reticulum
  12. 25. helper T cells that remain "unbiased" when they are first activated
Down
  1. 1. that encourages B cells to produce IgA antibodies
  2. 2. chippers that cut up proteins into peptides
  3. 3. cells have the ability to _______ when activated
  4. 4. hypermutation/The rearranged genes for the BCR can mutate to increase the affinity of the BCRs for their cognate antigen
  5. 5. selection/referred to as the second test to test for tolerance of self
  6. 6. order of choice of gene segments by recombination
  7. 9. cellular protein that catalyzes the release of CLIP and allows an exogenous protein to be loaded into the groove of the class II MHC molecule
  8. 10. main antibody class that guards the mucosal surfaces of the body
  9. 14. produced by helper T cells that "recharges" NK cells
  10. 15. transporter proteins involved in MHC molecule presentation
  11. 18. selection/the process of testing T cells for MHC restriction- "Do you have receptors on that recognize one of the self MHC molecules which I am expressing on my surface?"
  12. 20. cells/These cells are known to function as the "brains" of the immune system
  13. 23. antibody that defends against parasites and causes anaphylactic shock