Exam 2 Review

1234567891011121314151617181920212223
Across
  1. 5. positive/T cells that express both CD4 and CD8 co-receptor molecules
  2. 6. transporter proteins involved in MHC molecule presentation
  3. 11. cells that have never been activated by encountering their cognate antigen
  4. 15. produced by helper T cells that "recharges" NK cells
  5. 17. tiny region of the cognate antigen that a B cell receptor actually binds to is called its _______
  6. 18. eating"
  7. 19. cells/These cells are known to function as the "brains" of the immune system
  8. 20. chippers that cut up proteins into peptides
  9. 21. main antibody produced when a virgin B cell gets first activated
  10. 22. T cells generally express the _____ co-receptor
  11. 23. that encourages B cells to produce IgA antibodies
Down
  1. 1. T cells generally express the _____ co-receptor
  2. 2. hypermutation/The rearranged genes for the BCR can mutate to increase the affinity of the BCRs for their cognate antigen
  3. 3. many BCRs are brought close together on the B cell surface; this is needed to generate an activation signal
  4. 4. selection/the process of testing T cells for MHC restriction- "Do you have receptors on that recognize one of the self MHC molecules which I am expressing on my surface?"
  5. 7. cellular protein that catalyzes the release of CLIP and allows an exogenous protein to be loaded into the groove of the class II MHC molecule
  6. 8. main antibody class that guards the mucosal surfaces of the body
  7. 9. order of choice of gene segments by recombination
  8. 10. selection/referred to as the second test to test for tolerance of self
  9. 12. cells have the ability to _______ when activated
  10. 13. helper T cells that remain "unbiased" when they are first activated
  11. 14. factor that stimulates the proliferation of helper T cells, and growth factor for B cells
  12. 15. chain/This molecule sits in the groove of the MHC II molecule and keeps it from picking up other peptides in the endoplasmic reticulum
  13. 16. switching/B cell changes the class of antibody it produces
  14. 21. antibody that defends against parasites and causes anaphylactic shock