Extracellular Matrix

2. the major protein involved in maintain adherents junctions; connects to actin cytoskeleton across cells and requires calcium for function
3. the major protein filament that comprises the basal lamina
7. connects intermediate filaments of a cell to the basal lamina through integrins
9. long unbranched oligosaccharide that provides resistance to compressive forces
12. a GAG with a core protein base with 95% by weight repetitive disaccharides
13. a major ECM protein that exists in triple helix fibrils and provides tensile strength
14. a group of diseases that involves mutant or missing collagen alleles
15. a layer of tissue that contains fibroblasts and connective tissue

1. form aqueous channels between cells and allow regulated transfer of materials
4. when a mutation in a single copy of a gene causes an undesirable phenotype
5. prevents diffusion of larger molecules from the apical to basal side of an epithelial sheet
6. connects intermediate filaments between two cells
8. a protein that has binding sites for collagen, integrins, and GAGs that are revealed under tension
10. transmembrane receptor proteins that form focal adhesions, connect the cytoskeleton to the ECM, and are involved in bi-directional signaling pathways
11. an outer sheet-like layer of cells that provides separation between compartments in the body