Extracellular matrix

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Across
  1. 6. - Inactive intracellular precursor form of collagen
  2. 7. - Triple helical basic structural unit formed after cleavage of procollagen
  3. 10. - Glycoprotein defective in Marfan syndrome
  4. 12. - Autosomal recessive disorder caused by CFTR mutation leading to thick mucus
  5. 14. - Major structural protein of extracellular matrix and most abundant protein in the body
  6. 15. - Long unbranched polysaccharides present in proteoglycans
Down
  1. 1. - Copper containing enzyme responsible for collagen cross linking
  2. 2. - GAG lacking sulfate groups and important for lubrication
  3. 3. - Major glycoprotein of basement membrane responsible for selective filtration
  4. 4. - ECM glycoprotein involved in cell adhesion and metastasis prevention
  5. 5. - Special arrangement of collagen fibers helping in mineralization
  6. 8. - Infectious misfolded protein causing spongiform encephalopathy
  7. 9. - Protein that provides elasticity and recoil to tissues like lungs and blood vessels
  8. 11. - Syndrome characterized by tall stature, long fingers and aortic aneurysm
  9. 13. - Vitamin C deficiency disorder causing defective hydroxylation of collagen