Fetal Skeletal

1. abnormal development of the cartilaginous and osseous tissues resulting in bones that appear shortened, thin, deformed, or that fail to form at all.
3. abducted thumb, associated with dwarfism
6. second most common lethal type, decreased bone mineralization, abnormal bone formation
7. shortening of the entire limb
10. club hand
13. mildest type of OI
14. most severe type of OI
16. extra digits on hand or foot
17. clubfoot
19. permanent flexion of finger
20. shortening of the distal segments (hands, feet)
21. bent limbs, short and bowing of the long bones
23. shortening of the middle segments (radius, ulna, tib, fib)

2. lobster claw split hand or foot
4. severe micromelia, polydactyly, 3 types
5. increased frequency in the Amish community, short limbs, polydactyly, cardiac defects, (chondroectodermal dysplasia)
8. permanent incurvature of a finger (usually 5th: pinky), common in T21
9. most common lethal form of skeletal dysplasia, severe micromelia, decreased thoaric circumference, short curved "telephone reciever" femurs, flat vertebral bodies, champagne cork appearing abdomen, cloverleaf skull
11. exaggerated gap between 1st and 2nd digits
12. shortening of the proximal long bones (femur and humerus)
15. cutaneous or osseous fusion of digits
18. connective tissue disorder caused by defects in type 1 collagen found in skin, ligaments, tendons, and bone, results in multiple fractures, hypomineralization, and brittle bones, 4 main types ranging in severity
22. most common nonlethal form, trident configuration of hands, enlarged head, low nasal bone, rhizomelia, 2 forms