Final year medical student: INR

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Across
  1. 4. Chronic intake of this substance can elevate INR by potentiating the effects of warfarin. (6 letters)
  2. 6. One of the newer anticoagulants that doesn't require INR monitoring like warfarin. (10 letters)
  3. 9. This protein, synthesized by the liver, becomes carboxylated in a vitamin K-dependent process. (11 letters)
  4. 10. A condition in which both PT and aPTT are elevated, but INR is primarily used for monitoring its treatment. (14 letters)
  5. 12. An increased risk when the INR is below therapeutic range. (9 letters)
  6. 13. A target INR value for a patient with mechanical heart valves. (5, 6 letters: _ _ _ _ _ - _ _ _ _ _ _)
  7. 14. Another name for Factor II, which plays a role in the clotting cascade. (11 letters)
  8. 15. A reversal agent for life-threatening bleeding in patients taking direct factor Xa inhibitors. (9 letters)
Down
  1. 1. A primary indication for long-term anticoagulation therapy with a goal INR of 2-3. (9,10 letters: _ _ _ _ _ _ _ _ _ - _ _ _ _ _ _ _ _ _ _)
  2. 2. reticularis A condition characterized by purple, net-like skin discoloration, a rare side effect of warfarin therapy. (21 letters: _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _)
  3. 3. A significant side effect associated with an excessively high INR. (8 letters)
  4. 5. Class of anticoagulants that directly affect the INR, necessitating regular monitoring. (8 letters)
  5. 7. Enzymatic group affecting the metabolism of many anticoagulants, thereby impacting INR. (3 letters)
  6. 8. K A sudden elevation in this dietary component can decrease INR by antagonizing warfarin's mechanism. (7 letters)
  7. 11. A recommendation for someone on warfarin undergoing minor dental procedures. (13 letters: _ _ _ _ _ _ _ _ _ - _ _ _ _)