Final year pharmacy: INR

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Across
  1. 3. Ratio comparing a patient's prothrombin time to a standard. (3 letters)
  2. 4. A high INR value may indicate this state, increasing the risk of hemorrhage. (10 letters)
  3. 6. An INR value ideal for someone on anticoagulation due to atrial fibrillation. (3,6 letters: _ _ _ - _ _ _ _ _)
  4. 8. One of the vitamin K-dependent clotting factors affected by warfarin. (7 letters)
  5. 9. Enzyme system largely responsible for warfarin metabolism, affecting INR values. (4 letters)
  6. 13. INR levels below therapeutic range may indicate this state, increasing the risk of thrombosis. (13 letters)
  7. 14. The 'N' in INR stands for this word. (9 letters)
  8. 15. Natural substance, required for clotting factor synthesis, inhibited by warfarin. (7 letters)
Down
  1. 1. A genetic polymorphism affecting warfarin metabolism, impacting INR response. (4,4 letters: _ _ _ _ - _ _ _ _)
  2. 2. This class of drugs can significantly elevate INR and risk of bleeding when combined with warfarin. (8 letters)
  3. 5. A dietary component that may lead to fluctuating INR values when its intake is inconsistent. (7 letters)
  4. 7. A direct-acting oral anticoagulant that doesn't require routine INR monitoring like warfarin. (10 letters)
  5. 10. This test, along with INR, helps monitor warfarin therapy. (2 letters)
  6. 11. Antagonist used to reverse the effects of warfarin in cases of excessively high INR. (9 letters)
  7. 12. This organ's impairment might affect warfarin metabolism and subsequently INR values. (5 letters)