Genetics of cancer

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Across
  1. 3. inactivation of gene leads to increased likelihood of cancer (constrains cell proliferation)
  2. 6. Changes of an individual base pair of a DNA sequence
  3. 7. Part of a chromosome is joined to another chromosome
  4. 8. Tumour suppressor gene present in over 50% of all cancers
  5. 9. from single base pairs to whole gene, to large region of chromosome or entire chromosome, This can be detected by karyotype analysis (structural abnormality)
Down
  1. 1. a cancer inducing gene
  2. 2. normal gene likely to be involved in essential functions (proliferation & differentiation)
  3. 4. A heritable change in genetic material
  4. 5. increased copies of a gene contributing to oncogenesis by increasing expressions of the gene