Genomics Lab Week 2019

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Across
  1. 2. The process of determining the order of nucleotides in DNA
  2. 6. A threadlike structure of nucleic acids and protein found in the nucleus of most living cells, carrying genetic information in the form of genes
  3. 7. Provides whole genome/specific genome region analysis to detect copy number variants (CNVs)
  4. 8. A type of tumor that occurs in the brain and spinal cord; begins in the gluey supportive cells that surround nerve cells and help them function
  5. 9. An imaging technique that visualizes the distribution of a molecular species based solely on the properties of fluorescence emission
  6. 13. an interdisciplinary field of biology focusing on the structure, function, evolution, mapping, and editing of genomes
  7. 14. The first step of gene expression, in which DNA is copied into RNA by the enzyme RNA polymerase
  8. 15. A process of purification of DNA from a sample using a combination of physical and chemical methods
  9. 16. The motion of dispersed particles relative to a fluid under the influence of a spatially uniform electric field
  10. 18. Inhibits DNA synthesis to trap cells in S-phase
  11. 20. Pac-Man's original name
  12. 22. The number and appearance of chromosomes in the nucleus of a eukaryotic cell
  13. 23. Recruited by Dr. Dewald to Mayo Clinic where he joined Dr. Dewald and Dr. Jenkins to co-direct the Cytogenetics Laboratory, with Jack Spurbeck, he modified the Thermotron drying chamber for cytogenetic preparations
Down
  1. 1. A device which controls temperature and humidity and is used in the preparation of microscope slides for chromosome analysis to obtain optimum quality, spreading, and morphology of metaphase chromosomes
  2. 3. A type of biological cell that synthesizes the extracellular matrix and collagen, produces the structural framework (stroma) for animal tissues, and plays a critical role in wound healing
  3. 4. A process in which proteins or nucleic acids lose the quaternary, tertiary, and secondary structures present in their native state, by application of some external stress or compound
  4. 5. Co-director of the Genomics Laboratory and Program Director for the Clinical Molecular Genetics Fellowship, a prolific researcher and made substantial contributions to the field of molecular genetics, had a deep knowledge of cystic fibrosis, familial amyloidosis, and mitochondrial disorders (often stating that “genetics would make a fine hobby")
  5. 7. The presence of cancerous cells that have the ability to spread to other sites in the body (metastasize) or to invade nearby and destroy tissues
  6. 10. A short nucleic-acid chain usually consisting of up to approximately 20 nucleotides
  7. 11. The emission of light by a substance that has absorbed light or other electromagnetic radiation
  8. 12. A phenomenon in which single-stranded DNA or RNA molecules anneal to complementary DNA or RNA
  9. 17. Existing at or dating from birth
  10. 19. A pioneer in the field of FISH testing, founder and first Chair of the Division of Laboratory Genetics at Mayo Clinic
  11. 21. A stage of mitosis in which chromosomes are at their second-most condensed and coiled stage, which makes them most suitable for visual analysis