Get to Know Immunology Basics

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Across
  1. 1. an immune response that does not involve antibodies but rather involves antigen presenting cells and T-cell lymphocytes
  2. 6. a subtype of a thymus-derived lymphocyte that expresses the co-receptor protein CD4
  3. 9. short DNA sequences that serve as the binding sites and allow for somatic recombination
  4. 10. an immunoglobulin expressed on B cell surfaces
  5. 12. a blood test marker for inflammation in the body
  6. 14. Y-shaped protein used by the immune system to identify and neutralize foreign objects
  7. 15. general designation of many of the different cytokines
  8. 16. leukocytes with multi-lobed nuclei and cytoplasmic granules
  9. 18. an immune cell that links the innate and adaptive arms of the immune system
  10. 19. a medication regimen used to manage and treat human immunodeficiency virus
  11. 21. a molecule that stimulates an immune response by activating leukocytes that fight disease
  12. 23. cell adhesion molecule
  13. 24. crystallized fragment of an antibody
  14. 26. transcription factor expressed in Treg cells that is needed for their function
  15. 28. a lymphocyte subtype that develops and matures in the bone marrow
  16. 29. a virus that attacks the body's immune system and if not treated can lead to AIDS
  17. 30. a cytokine that is critical for immunity against viral infections and is commonly known as type II interferon
Down
  1. 2. end product of a cascade that can kill pathogens
  2. 3. group of genes that code for proteins found on the surfaces of cells that help the immune system recognize foreign substances
  3. 4. lymphocytes with the effector function of targeting and killing virally infected cells
  4. 5. subpopulation of T cells that suppress immune responses
  5. 7. involved in stimulating B cells to produce antibody against extracellular pathogens
  6. 8. a cell wall component of gram negative bacteria
  7. 11. these are secreted by plasma cells and that function as antibodies in the immune response by binding with specific antigen
  8. 13. repeating molecular patterns on microbes that are recognized by PRRs on immune cells
  9. 15. cell surface ligands for leukocyte integrins
  10. 17. part of an innate immune response that kills infected cells kills by apoptosis
  11. 20. lymphocyte that matures in the thymus
  12. 22. highly pro-inflammatory cytokine produced by macrophages and T cells
  13. 25. reaction which occurs within an organism for the purpose of defending against foreign invaders
  14. 27. receptors on immune cells and epithelial cells that recognize and bind to PAMPs on microbes
  15. 31. transcription factor that helps activate the expression of many pro-inflammatory genes
  16. 32. the end stage of disease in a HIV infection