Getting to know Immunology!

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Across
  1. 2. Cell that is able to present antigens via MHC molecules to T cell receptors on T cells (Antigen presenting cells).
  2. 5. Receptors on B cells that bind antigens and transmits signal 1 to activate B cells (B cell receptor).
  3. 8. End stage of disease in HIV infection (Acquired immune deficiency syndrome).
  4. 9. Cell adhesion molecule.
  5. 10. Immune response.
  6. 11. Cytokines produced by macrophages and T cells that is highly pro-inflammatory.
  7. 15. Large granular lymphocyte that serves as a innate effector cell and induces apoptosis of target cells.
  8. 19. CD4 T cells involved in stimulating B cells to produce antibody against extracellular pathogens.
  9. 21. Part of antibody that consists of carboxy terminal halves of the two heavy chains disulfide-bonded to each other. Responsible for antibody effector function.
  10. 22. Immunoglobulin that is expressed on B cell surface (slg).
  11. 25. Cytokine produced by cD4 TH1 cells, CD8 T cells and NK cells. Primary actions are to act with IL-12 and induce TH1 differentiation and fully activate macrophages.
  12. 26. Family name for cytokines that help cells to resist viral infections.
  13. 27. The Ag receptor on T cells.
  14. 29. Protein family to which antibodies and B cell receptors belong (Ig).
  15. 31. Lymphocyte that upon activation can differentiate into plasma cells that secrete antibodies or into B memory cells.
Down
  1. 1. Cell wall component of gram negative bacteria which can be bound by TLR-4 on macrophages and dendritic cells (LPS).
  2. 3. End product of the Complement cascade that can kill pathogens directly by forming a pore in pathogen membrane leading to lysis (MAC).
  3. 4. CD4 T cells involved in activating macrophages and promoting CTL responses against intracellular pathogens.
  4. 6. Adaptive immune responses in which there is a major role for effector T cells (CMI)
  5. 7. T cells that express the co-receptor protein CD4 that once activated, it differentiates into distinct Thelper phenotypes with roles in adaptive immunity.
  6. 12. Molecule that is recognized as it original structure by antibodies, B cell receptor or T cell receptor (Ag).
  7. 13. T cell responsible for suppressing immune response.
  8. 14. Human immunodeficiency virus
  9. 16. Thymus-derived lymphocyte that can be either CD4 or CD8.
  10. 17. T cells that express co-receptor protein CD8 that once activated, it differentiates into cytotoxic T cells.
  11. 18. Designation for a family of cell surface molecules involved in the presentation of peptide antigens to T cells (Major histocompatibility complex).
  12. 20. Member of TNF receptor family expressed on certain cells that makes them susceptible to being killed by cells expressing Fas ligand.
  13. 21. Part of antibody responsible for antigen binding.
  14. 23. Transcription factor that causes several tissue-specific genes to be transcribed by a subpopulation of epithelial cells in the thymus (Autoimmune regulator).
  15. 24. Soluble acute phase response protein than can bind mannose on pathogens; can activate the lectin pathway of Complement (MBL).
  16. 25. Chemical messengers secreted by immune cells that help in their communication with other cells (IL).
  17. 28. Immunoglobulin that is secreted by plasma cells (Ab).
  18. 30. Transcription factor that helps activate the expression of many pro-inflammatory genes.