gone cAMPing

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Across
  1. 1. second messenger that activates protein kinase A
  2. 3. mediates most effects of cAMP by phosphorylating targets; in the case of the body’s response to epinephrine, it activates glycogen phosphorylase kinase and inactivates glycogen synthase
  3. 4. when a ligand like epinephrine binds this type of adrenergic receptor, it induces guanine exchange on a stimulatory G protein alpha subunit
  4. 6. TF that is phosphorylated by PKA and binds to CBP/P300 (a histone acetylase)
Down
  1. 1. gene regulatory sequence containing 5’-TGACGTCA-3’
  2. 2. binding to the effector enzyme AC can increase the rate of GTP hydrolysis; thus AC can act as this type of natural feedback mechanism limiting prolonged signaling (hint: stands for GTPase-activating protein)
  3. 3. hydrolyzes cAMP to AMP
  4. 5. catalyzes the synthesis of cAMP from ATP