Hematologic System & Problems Review Crossword

12345678910111213141516171819202122232425262728293031323334353637383940414243444546474849505152535455565758596061
Across
  1. 5. Enhances iron absorption when taken together
  2. 8. Smooth, beefy red tongue; seen in B12 or folate deficiency
  3. 10. Stimulates neutrophil production after chemo or bone marrow suppression
  4. 11. Gastric factor required for B12 absorption; absent in pernicious anemia
  5. 12. Deficiency causing macrocytic anemia; common in alcoholism and pregnancy
  6. 14. Genetic deficiency of factor VIII causing prolonged bleeding
  7. 15. Large RBCs from B12 or folate deficiency
  8. 19. Thrombotic thrombocytopenic purpura; microclots → low platelets + organ ischemia
  9. 20. Type of hemoglobin present at birth; persists in sickle cell after hydroxyurea
  10. 24. Undifferentiated cells forming all blood components
  11. 25. Platelet count <150K; increased bleeding risk
  12. 26. Purple blotches from subdermal bleeding; seen in ITP or TTP
  13. 29. Painful oral inflammation during chemo; risk for infection
  14. 31. Genetic hemoglobin defect causing sickled RBCs and vaso-occlusion
  15. 34. Large purple skin bruise from bleeding under skin
  16. 36. Lymphoma without Reed–Sternberg cells; multiple subtypes
  17. 39. Route for B12 replacement when IM or PO not tolerated
  18. 43. Increased immature neutrophils; indicates acute bacterial infection
  19. 44. Vaso-occlusion in sickle cell → ischemic pain and organ damage
  20. 46. Monoclonal antibodies targeting cancer cells; watch for infusion reactions
  21. 47. Syndrome from tumor breakdown → ↑K⁺, ↑PO₄³⁻, ↓Ca²⁺, ↑uric acid after chemo
  22. 49. Blood cell type that defends against infection
  23. 50. Process of blood cell formation in bone marrow
  24. 51. Autoimmune B12 deficiency from loss of intrinsic factor
  25. 54. Priority action when HIT suspected; prevents further thrombosis
  26. 55. Acute leukemia with myeloid origin; common in adults
  27. 56. Acute leukemia with lymphoid origin; most common in children
  28. 58. Liquid portion of blood carrying proteins, nutrients, and clotting factors
  29. 59. Yellow eyes from bilirubin buildup in hemolysis
  30. 61. Decreased RBCs or Hgb; causes fatigue, pallor, SOB
Down
  1. 1. ↓ in all cell lines: RBCs, WBCs, and platelets
  2. 2. Deficiency of all blood cell types from marrow suppression
  3. 3. Protein web trapping RBCs and platelets to form stable clot
  4. 4. Lowest blood count point after chemo; highest infection risk
  5. 6. Stem cell line producing RBCs, platelets, granulocytes
  6. 7. Excess RBC production; risk for thrombosis and hyperviscosity
  7. 9. Fever, night sweats, weight loss; seen in lymphoma
  8. 10. Donor T cells attack host tissues after stem cell transplant
  9. 13. Genetic microcytic anemia with abnormal Hgb synthesis
  10. 16. Mnemonic for multiple myeloma findings: ↑Ca, renal failure, anemia, bone lesions
  11. 17. Iron overload causing organ damage; treated with phlebotomy
  12. 18. Stem cell line giving rise to lymphocytes and plasma cells
  13. 21. Drug increasing fetal Hgb to reduce sickle cell crises
  14. 22. Cell fragment aiding clot formation; normal 150–400K
  15. 23. Small RBCs from iron deficiency or thalassemia
  16. 27. Absolute neutrophil count; <500 = severe infection risk
  17. 28. RBCs with low Hgb content; appear pale on smear
  18. 30. Disseminated intravascular coagulation; widespread clotting → bleeding
  19. 32. Spoon-shaped nails; seen in iron deficiency anemia
  20. 33. Needed for clotting factor synthesis; deficiency → bleeding
  21. 35. Immune thrombocytopenic purpura; autoimmune platelet destruction
  22. 37. Synthetic vasopressin stimulating factor VIII release in mild hemophilia A
  23. 38. Immature neutrophils; ↑ indicates bacterial infection
  24. 40. First responder WBCs; main defense against bacteria
  25. 41. Low neutrophil count; risk for severe bacterial infection
  26. 42. Small pinpoint hemorrhages; sign of low platelet count
  27. 45. Deficiency causes microcytic, hypochromic anemia; treat with PO or IV supplementation
  28. 48. Precautions include mask use, hand hygiene, avoiding fresh plants/foods/crowds/sick people
  29. 52. Type of anemia with bone marrow failure → pancytopenia
  30. 53. T-cell therapy reprogrammed to attack cancer cells; watch for cytokine storm
  31. 57. Malignant overproduction of immature WBCs in bone marrow
  32. 60. Blood cell that transports oxygen via hemoglobin