Hematology

12345678910111213141516171819202122232425262728293031
Across
  1. 2. The hemoglobin of sickle cell disease in which there are two normal A chains and two abnormal beta chains that fold poorly, causing the red blood cell to assume a sickle shape under low-oxygen conditions
  2. 4. Destructive reduction of circulating platelets after normal platelet production
  3. 6. Cellular excess in the peripheral blood
  4. 7. Selective growth of bone marrow stem cells into mature erythrocytes.
  5. 9. Unspecialized (undifferentiated) cells that are capable of becoming any type of blood cell
  6. 14. Process by which a specific part of the blood is removed by automated blood processing equipment and the remainder is transfused back into the patient (also called hemapheresis or pheresis)
  7. 17. White blood cell cancer of mature B lymphocytes called plasma cells that secrete antibodies
  8. 18. Genetic disorder in which a mutation in the gene for the beta chains of hemoglobin causes chronic anemia, pain, disability, organ damage, increased risk for infection, and early death as a result of poor blood perfusion
  9. 21. The period of greatest bone marrow suppression
  10. 22. Anemia caused by immunity problems in which individuals form antibodies against their own RBC membranes
  11. 23. Reddish-purple pinpoint hemorrhagic lesions in the skin
  12. 24. Clotting disorder causing thrombosis and hemorrhage
  13. 26. A reduction in white blood cells [WBCs]
  14. 28. Condition in which there is a deficiency of circulating red blood cells (RBCs) due to impaired cellular regulation of the bone marrow, which then fails to produce these cells
  15. 29. Condition in which there are lower-than-normal levels of neutrophils in the blood
  16. 30. The main type of hemoglobin in the fetus, having two normal A chains and two normal gamma chains that bind oxygen more tightly than does hemoglobin A or S
  17. 31. Spectrum of disorders in which there is reduced or absent production of one or more globin chains, leading to ineffective red blood cell maturation
Down
  1. 1. The process that dissolves fibrin clot edges with special enzymes to prevent over enlargement of a clot beyond the area where it is needed
  2. 3. Reduction in the number of circulating platelets from reduced platelet production
  3. 5. One of the chronic myeloproliferative neoplasms (MPNs) in which there is loss of cellular regulation and excessive proliferation of specific groups of abnormal myeloid cells that have decreased function
  4. 7. Mature red blood cells (RBCs)
  5. 8. Blood cancer that results from a loss of normal cellular regulation, leading to uncontrolled production of immature WBCs (“blast” cells) in the bone marrow
  6. 10. The multistep process of controlled blood clotting, resulting in localized blood clotting in damaged blood vessels to prevent excessive blood loss while continuing blood perfusion to all other areas
  7. 11. Cancers of the lymphoid cells and tissues with loss of cellular regulation and abnormal overgrowth of lymphocytes
  8. 12. Anemia that results from insufficient iron in the body
  9. 13. Anemia resulting from failure to absorb vitamin B12, caused by a deficiency of intrinsic factor (a substance normally secreted by the gastric mucosa), which is needed for intestinal absorption of vitamin B12
  10. 15. Normal adult hemoglobin with two normal A chains and two normal B chains
  11. 16. Reduction in the number of red blood cells (RBCs), the amount of hemoglobin, or the hematocrit (percentage of packed RBCs per deciliter of blood)
  12. 19. Classification of leukemic cells arising from the myeloid pathways; also known as myelogenous, myelocytic, or myeloblastic cells
  13. 20. Condition in which there is a deficiency of red blood cells, white blood cells, and platelets
  14. 25. A complex, multistep process by which blood forms a protein-based structure (clot) in an appropriate area of tissue injury to prevent excessive bleeding while maintaining whole-body blood flow (perfusion)
  15. 27. The total arterial blood flow through the tissues (peripheral perfusion) and blood that is pumped by the heart (central perfusion)