Hematology Homework 4

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Across
  1. 2. Gene associated with thrombopoietin receptor mutations in some myeloproliferative neoplasms.
  2. 4. Formation of a blood clot, a major complication of polycythemia vera and essential thrombocythemia.
  3. 8. Abnormal development or maturation of blood cells.
  4. 9. Bone marrow cells responsible for producing platelets.
  5. 10. Decreased red blood cell mass or hemoglobin, commonly seen in MDS and PMF.
  6. 14. Mutation commonly associated with polycythemia vera and other myeloproliferative neoplasms.
  7. 17. Myeloproliferative neoplasm characterized by persistently elevated platelet counts.
  8. 18. Enlargement of the spleen, commonly associated with primary myelofibrosis.
  9. 20. Abnormally increased red blood cell mass.
  10. 21. Group of disorders characterized by ineffective hematopoiesis and dysplastic blood cells.
  11. 22. Replacement of normal bone marrow tissue with fibrous tissue.
Down
  1. 1. Decreased number of one or more types of circulating blood cells.
  2. 3. Excessive production of red blood cells, often associated with a JAK2 mutation.
  3. 5. Bone marrow disorder characterized by fibrosis and teardrop-shaped red blood cells.
  4. 6. Increase in all three myeloid cell lines in the bone marrow.
  5. 7. Abnormally shaped red blood cells commonly seen in primary myelofibrosis.
  6. 11. Itching after a warm shower, classically associated with polycythemia vera.
  7. 12. Immature precursor cells that may increase with disease progression.
  8. 13. Abnormally increased platelet count.
  9. 15. Gene that may be mutated in essential thrombocythemia and primary myelofibrosis.
  10. 16. Common driver mutation found in several myeloproliferative neoplasms.
  11. 19. Hormone commonly decreased in polycythemia vera.