Heme Metabolism

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Across
  1. 4. Binding one O2 increases affinity for next (13)
  2. 5. Binds deoxy-Hb, reduces O2 affinity (3)
  3. 6. CO2 and H+ facilitate O2 displacement from Hb (7)
  4. 8. Low oxygen affinity state, stabilized by salt bridges (5)
  5. 10. Moves into RBC to maintain electrical neutrality (8)
Down
  1. 1. Catalyzes CO2 hydration in RBCs (17)
  2. 2. CO2 bound to Hb globin chains (9)
  3. 3. O2 dissociation curve shifts during exercise/fever (5)
  4. 7. Buffers H+ ions in Hb (9)
  5. 9. Oxygenation of Hb promotes CO2 dissociation (4)